Spike, RSV and ReadiSorb®

POINTS OF INTEREST

Copy of email follows:
From: Dr. Tim Guilford
Sent: March 13, 2024
To: Carolyn Winsor
Subject: Spike, RSV and ReadiSorb®

Carolyn, here is an update leading to the recently published articles I mentioned on the zoom call. The articles are linked toward the end of this email. Also, please let me know if the PDF (follow this link) is helpful in understanding the figures from the papers. I think most people I’ve contacted don’t read the paper!!

An update on recent studies conducted with ReadiSorb® Liposomal Glutathione (RLG). The link is to the advantages page on our website to show the clinical studies and research demonstrating the advantage of RLG over NAC and plain glutathione (GSH). Please note RLG restores glutathione (GSH) in both infectious and metabolic conditions such as diabetes, which deplete GSH. The severity of Covid-19 was tripled in individuals with Diabetes (4).

Over the course of the COVID-19 pandemic, I was co-author of three papers discussing the role of glutathione deficiency and the illness caused by SARS-CoV-2 (5-7). In the articles, the reviewers allowed the statement, Viruses deplete glutathione to facilitate replication. The last of the series discusses the use of glutathione in the prevention of Immunothrombosis “The Role of Glutathione in Prevention of COVID-19 Immunothrombosis” (7). We now have cell culture confirmation of the role of RLG in the management of the immunothrombosis of COVID-19 (2). The study shows the Spike protein itself triggers many of the immune and thrombotic changes seen in SARS CoV-2 infection (2). Examples of the benefit of RLG on the immunologic and fibrin clot information are illustrated in the attached PDF.

Two Studies regarding the impact of RLG on the effects of different viruses were published in 2024:

  1. A recently published study on the Spike protein of COVID-19  in cell culture confirms the role of glutathione in the prevention of immunothrombosis related to the Spike protein of COVID (2). “Evaluation of Glutathione in Spike Protein of SARS-CoV-2 Induced Immunothrombosis and Cytokine Dysregulation” was conducted using RLG.
  2. A study conducted in GSH depleted mice published in January, demonstrates the use of RLG in the management of Respiratory Syncytial Virus (RSV) in neonatal mice depleted of GSH: “Liposomal Glutathione Augments Immune Defenses against Respiratory Syncytial Virus in Neonatal Mice Exposed in Utero to Ethanol,” (8)

I look forward to any suggestions you may have.

Best,
Tim
Tim Guilford, MD
ReadiSorb® Liposomal Glutathione (RLG)

Tim Guilford, MD
Dr. Guilford graduated from Johns Hopkins University and the University of Texas Medical Branch Medical School.
Dr. Guilford has been in clinical practice since 1979. In 1985 he introduced complementary medical approaches into his practice. The concept that chronic inflammation functions as a causative factor in illness became apparent while he was the director of a laboratory specializing in in-vitro allergy and viral immunology testing (1982 -1992). His interest in yeast and mold related health problems began with the development of an immunologic test for IgG to Candida albicans, which was published in the Journal of Advancement in Medicine (ACAM journal), volume 1, 1986.
He began using metal detoxification methods in 1995, and research into the toxicity of mercury lead to the observation that in addition to its role as an antioxidant, glutathione is critical in the defense against heavy metals. His interest in the mechanisms of inflammation and the role of toxins has led to research related to the glutathione antioxidant and detoxification pathways.
Dr. Guilford’s study of the role that glutathione plays in the basic mechanism of many diseases led to his formulation of ReadiSorb Glutathione, a liposome encapsulation of reduced glutathione, over 8 years ago. A number of studies related to the properties of liposomal glutathione have been published and more are in progress.

References

  1. Lage SL, Amaral EP, Hilligan KL, Laidlaw E, Rupert A, Namasivayan S, et al. Persistent Oxidative Stress and Inflammasome Activation in CD14(high)CD16(-) Monocytes From COVID-19 Patients. Front Immunol. 2021;12:799558. PMCID: PMC8795739. https://www.ncbi.nlm.nih.gov/pubmed/35095880
  2. Norris B, Chorbajian A, Dawi J, Mohan AS, Glassman I, Ochsner J, et al. Evaluation of Glutathione in Spike Protein of SARS-CoV-2 Induced Immunothrombosis and Cytokine Dysregulation. Antioxidants. 2024;13(3):271. https://www.mdpi.com/2076-3921/13/3/271
  3. Liang Z, Soriano-Castell D, Kepchia D, Duggan BM, Currais A, Schubert D, et al. Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors. Free Radic Biol Med. 2022;180:33-51. PMCID: PMC8840979. https://www.ncbi.nlm.nih.gov/pubmed/34999187
  4. Gregory JM, Slaughter JC, Duffus SH, Smith TJ, LeStourgeon LM, Jaser SS, et al. COVID-19 Severity Is Tripled in the Diabetes Community: A Prospective Analysis of the Pandemic’s Impact in Type 1 and Type 2 Diabetes. Diabetes Care. 2021;44(2):526-32. PMCID: PMC7818316. https://www.ncbi.nlm.nih.gov/pubmed/33268335
  5. Guloyan V, Oganesian B, Baghdasaryan N, Yeh C, Singh M, Guilford F, et al. Glutathione Supplementation as an Adjunctive Therapy in COVID-19. Antioxidants (Basel). 2020;9(10). PMCID: PMC7601802. https://www.ncbi.nlm.nih.gov/pubmed/32992775
  6. Yegiazaryan A, Abnousian A, Alexander LJ, Badaoui A, Flaig B, Sheren N, et al. Recent Developments in the Understanding of Immunity, Pathogenesis and Management of COVID-19. Int J Mol Sci. 2022;23(16). PMCID: PMC9409103. https://www.ncbi.nlm.nih.gov/pubmed/36012562
  7. Glassman I, Le N, Mirhosseini M, Alcantara CA, Asif A, Goulding A, et al. The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review. Front Biosci (Landmark Ed). 2023;28(3):59. PMCID: PMC10406467. https://www.ncbi.nlm.nih.gov/pubmed/37005767
  8. Gauthier TW, Ping X-D, Harris FL, Brown LAS. Liposomal Glutathione Augments Immune Defenses against Respiratory Syncytial Virus in Neonatal Mice Exposed in Utero to Ethanol. Antioxidants. 2024;13(2):137. https://www.mdpi.com/2076-3921/13/2/137

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