Immune Training or Risk

Epigenetic Changes From mRNA Vaccines

A new study shows that mRNA‑vaccinations leave profound traces in the immune system. But what does long-term immunity generated in this way mean for health? In their 2024 study, Prof. Jan Rybniker and his team showed that SARS-CoV-2 mRNA vaccination triggers permanent epigenetic changes in immune cells – especially in macrophages. According to the study, it changes a certain protein in the cell nucleus – the so-called histone H3 at the K27 site – by means of a chemical marker (acetylation). This marker acts as a switch-on sign for many genes that have to do with inflammation. This means that the cells are permanently more ready to trigger inflammatory reactions.

Blood tests showed that one vaccination changes the activity of 268 genes and the second vaccination changes the activity of 2,518 genes. The immune system, according to the authors, is “trained” by this – a kind of memory for a rapid, non-specific immune response.

Permanent Stress For the Immune System

In a critical commentary, the health scientist Prof. Harald Walach refers to the downside of this training success: A chronically increased propensity to inflammation could increase the risk of exhaustion, autoimmune diseases or even cancer in the long term. Walach does not consider the activation of more than 2,500 genes after multiple vaccinations to be an advantage, but a possible epigenetic stress factor.

Sources:
Simonis et al., Molecular Systems Biology, 2025; doi: 10.1038/s44320-025-00093-6 https://harald-walach.de/2025/04/30/modrna-impfungen-gegen-sars-cov-2-veraendern-die-empfindlichkeit-des-immunsystems/#more-5371

An Exclusive Translated Article for P2P Supporters
Published October 2025

From an article in Raum&Zeit, Volume 43, Issue #256, July/Aug. 2025
Translation & redaction by: Carolyn L. Winsor, P2P Consulting
© Copyright 2025, raum&zeit, Wolfratshausen, Germany
AI Digital and online translation assistance utilized.

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